HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,5-Dichloro-N-[(2S)-2-(4-fluorophenyl)pent-4-en-1-yl]-N-methylbenzamide → 6-Cyano-N-[(2S)-2-(4-fluorophenyl)-4-oxobutyl]-N-methylindane-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,5-Dichloro-N-[(2S)-2-(4-fluorophenyl)pent-4-en-1-yl]-N-methylbenzamide | HCID 68978638 | — |
| Reactant | 6-cyano-N-[(2S)-2-(4-fluorophenyl)pent-4-en-1-yl]-N-methylindane-4-carboxamide | HCID 68979020 | — |
| Product | 6-Cyano-N-[(2S)-2-(4-fluorophenyl)-4-oxobutyl]-N-methylindane-4-carboxamide | HCID 11222271 | — |
Reaction Steps
The compound was synthesized in an analogous way to that of Method 21b but using 6-cyano-N-[(2S)-2-(4-fluorophenyl)pent-4-en-1-yl]-N-methylindane-4-carboxamide rather than 3,5-dichloro-N-[(2S)-2-(4-fluorophenyl)pent-4-en-1-yl]-N-methylbenzamide (yield, 89%). 1H NMR (300 MHz, CDCl3): 0.9-4.2 (cm, 14H), 5.9 (s, <1H), 6.6-8.2 (cm, 6H), 8.0 (s, <1H), 9.8 (s, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07402581B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-e9016bc704ad4e52b031bf2fa137d724 |
| Source note | uspto-grants-2008_07 |