Ethyl trimethylsilyl malonate → Ethyl 3-[2,4-dichloro-5-(2-chloro-4,6-difluorophenylamino)phenyl]-3-oxopropionate
Reaction equation
C([Li])CCC.[C:6]([O:16][CH2:17][CH3:18])(=[O:15])[CH2:7][C:8]([O:10][Si](C)(C)C)=O.[Cl:19][C:20]1[CH:28]=[C:27]([Cl:29])[C:26]([NH:30][C:31]2[C:36]([F:37])=[CH:35][C:34]([F:38])=[CH:33][C:32]=2[Cl:39])=[CH:25][C:21]=1C(Cl)=O>CCCCCC.C(OCC)C.C(COC)OC.C(OCC)(=O)C>[Cl:19][C:20]1[CH:28]=[C:27]([Cl:29])[C:26]([NH:30][C:31]2[C:36]([F:37])=[CH:35][C:34]([F:38])=[CH:33][C:32]=2[Cl:39])=[CH:25][C:21]=1[C:8](=[O:10])[CH2:7][C:6]([O:16][CH2:17][CH3:18])=[O:15]Participants
Reactant 3
Product 1
Reagents, catalysts & solvents 4
Conditions
- Temperature
- -75 °C
Procedure
1.4 ml of a 1.6 M solution of butyllithium in hexane was added to a solution of 3.47 g (17.0 mmol) of ethyl trimethylsilyl malonate in 45 ml of diethyl ether at −75° C. in such a way that the temperature did not rise above −60° C. The mixture was then stirred at −75° C. for 30 minutes. The 2,4-dichloro-5-(2-chloro-4,6-difluorophenylamino)benzoyl chloride was dissolved in 45 ml of dimethoxyethane and added dropwise in 40 minutes. The mixture was slowly warmed to 10° C. and stirred at this temperature for 2.5 hours. The reaction mixture was diluted with ethyl acetate and washed twice each with 250 ml portions of water and saturated sodium bicarbonate solution. The organic phase was dried and concentrated. 3.88 g of the crude mixture were obtained and were reacted without further purification in the next stage.
Workup
- customdid not rise above −60° C
- additionadded dropwise in 40 minutes
- temperatureThe mixture was slowly warmed to 10° C.
- stirringstirred at this temperature for 2.5 hours
- washwashed twice each with 250 ml portions of water and saturated sodium bicarbonate solution
- customThe organic phase was dried
- concentrationconcentrated
Sources & evidence
- ORD record
- ord-137ca073d3944f19b6d5b0a457ad8aa8
- Source dataset
- uspto-grants-2008_07
- Patent number
- US07402674B2
Reaction notes
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