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3-Aminopyridine → ethyl 2-[2,4-dichloro-5-(2-chloro-4,6-difluoroanilino)benzoyl]-3-(pyridin-3-ylamino)prop-2-enoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Aminopyridine | HCID 10009 | — |
| 反応物 | Ethyl 2-[2,4-dichloro-5-(2-chloro-4,6-difluorophenylamino)benzoyl]-3-dimethylaminoacrylate | HCID 68796206 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | ethyl 2-[2,4-dichloro-5-(2-chloro-4,6-difluoroanilino)benzoyl]-3-(pyridin-3-ylamino)prop-2-enoate | HCID 178471940 | 104.4% |
反応手順
A solution of 30 mg (0.06 mmol) of ethyl 2-[2,4-dichloro-5-(2-chloro-4,6-difluorophenylamino) benzoyl]-3-dimethylaminoacrylate and 15 mg (0.16 mmol) of 3-aminopyridine in 2 ml of toluene were heated at 150° C. for 7 hours. Concentration resulted in 33 mg of the desired product, which were employed without further purification in the next stage.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07402674B2 |
| 出典データセット | uspto-grants-2008_07 |
| ORD ID | ord-c37c822198a648f091a061bbc8acbaa4 |
| 出典メモ | uspto-grants-2008_07 |