反应详情

A solution of 30 mg (0.06 mmol) of ethyl 2-[2,4-dichloro-5-(2-chloro-4,6-difluorophenylamino) benzoyl]-3-dimethylaminoacrylate and 15 mg (0.16 mmol) of 3-aminopyridine in 2 ml of toluene were heated at 150° C. for 7 hours. Concentration resulted in 33 mg of the desired product, which were employed without further purification in the next stage.

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