Phenylboronic Acid → HCID 24871617, compound

HRID 749830Notes

Reaction equation

HRID 749830 reaction equation
C(OC([N:8]1[CH2:17][CH2:16][C:15]2[C:11](=[C:12]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)[N:13]([C:18]3[CH:23]=[CH:22][CH:21]=[C:20]([C:24]([F:27])([F:26])[F:25])[CH:19]=3)[N:14]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.C(OC(N1CCC2C(=C(OS(C(F)(F)F)(=O)=O)N(C3C=CC=C(C(F)(F)F)C=3)N=2)CC1)=O)(C)(C)C.C1(B(O)O)C=CC=CC=1>>[C:28]1([C:12]2[N:13]([C:18]3[CH:23]=[CH:22][CH:21]=[C:20]([C:24]([F:25])([F:26])[F:27])[CH:19]=3)[N:14]=[C:15]3[C:11]=2[CH2:10][CH2:9][NH:8][CH2:17][CH2:16]3)[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1

Participants

4

Reactant 3

HCID 66827Phenylboronic AcidHCID 67268842HCID 67268842, compoundHCID 86598386HCID 86598386, compound

Product 1

HCID 24871617HCID 24871617, compound

Procedure

3-Phenyl-2-(3-trifluoromethyl-phenyl)-4,5,7,8-tetrahydro-2H-1,2,6-triaza-azulene-6-carboxylic acid tert-butyl ester. The desired compound (172.0 mg) was prepared from 279.1 of mg of 3-trifluoromethanesulfonyloxy-2-(3-trifluoromethyl-phenyl)-4,5,7,8-tetrahydro-2H-1,2,6-triaza-azulene-6-carboxylic acid tert-butyl ester (made from (3-trifluoromethyl-phenyl)-hydrazine as in Example 176, Steps A and B) and 0.21 g of phenylboronic acid, as described in Example 177, Step C. MS (ESI): exact mass calculated for C25H26F3N3O2, 457.20; found, m/z 458.1 [M+H]+.

Sources & evidence

ORD record
ord-8759012613ca41c3b1e4827be5dcd64d
Source dataset
uspto-grants-2008_07
Patent number
US07402680B2

Reaction notes

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