反应详情

A solution of racemic [1-benzyloxy-3-methoxy-2-cyclohexanoxy]tert-butyl-dimethylsilane, 51e, (3.4 g, 9.7 mmol) was dissolved in ethyl acetate (50 mL) and hydrogenated under 45 PSI of hydrogen with Pd—C 10% for 1 h. The reaction mixture was filtered over a nylon/fiberglass filter to provide, after concentration in vacuo 2.72 g of desired product 51f. This material was used directly in the next step without further purification.

1. filtrationThe reaction mixture was filtered over a nylon/fiberglass
2. filtrationfilter
3. customto provide
4. concentrationafter concentration in vacuo 2.72 g of desired product 51f
5. customThis material was used directly in the next step without further purification