Hydrochloric Acid → HCID 66869241, compound

HRID 749954Notes

Reaction equation

HRID 749954 reaction equation
C(OC([N:8]1[CH2:12][CH2:11][CH2:10][C@H:9]1[CH2:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([O:21][C:22]2[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][CH:23]=2)=[CH:17][CH:16]=1)=O)(C)(C)C.Cl>O1CCOCC1>[ClH:28].[Cl:28][C:25]1[CH:26]=[CH:27][C:22]([O:21][C:18]2[CH:19]=[CH:20][C:15]([O:14][CH2:13][C@@H:9]3[CH2:10][CH2:11][CH2:12][NH:8]3)=[CH:16][CH:17]=2)=[CH:23][CH:24]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 44819169HCID 44819169, compound

Product 1

HCID 66869241HCID 66869241, compoundYield 130.8%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To the product from step 3 (6.30 g, 15.6 mmol) was added 4 M HCl in dioxane (62 mL). The resulting mixture was stirred at ambient temperature overnight. The solvent was removed in vacuo. The crude product was triturated with ether and dried under reduced pressure to afford the title product (3.47 g, 65%) as an off-white solid.

Workup

  1. customThe solvent was removed in vacuo
  2. customThe crude product was triturated with ether
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-5c007bccf9f1433dbce4886bc02587ce
Source dataset
uspto-grants-2008_07
Patent number
US07402684B2

Reaction notes

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