Hydrochloric Acid → HCID 69004848, compound

HRID 749988Notes

Reaction equation

HRID 749988 reaction equation
[ClH:1].C(OC([N:9]1[CH2:14][CH2:13][CH2:12][CH2:11][C@H:10]1[CH2:15][OH:16])=O)(C)(C)C>O1CCOCC1>[ClH:1].[NH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][C@H:10]1[CH2:15][OH:16]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 6933954tert-Butyl (2S)-2-(hydroxymethyl)piperidine-1-carboxylate

Product 1

HCID 69004848HCID 69004848, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A 4M HCl solution in dioxane (30 mL) was added to (S)-2-Hydroxymethyl-piperidine-1-carboxylic acid tert-butyl ester (5.12 g, 23.78 mmol). The mixture was stirred at rt for 3 h. The solvent was removed in vacuo to yield the title product as a hydrochloride salt (3.43 g, 95%).

Workup

  1. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-2a23a9fc9fe34ee697096d5e95dbc292
Source dataset
uspto-grants-2008_07
Patent number
US07402684B2

Reaction notes

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