反应详情

温度

55 °C

To the product from Example 58 (25 mg, 0.0612 mmol) in 1,4-dioxane (1 mL) was added 12N HCl (0.8 mL) and the resulting mixture was stirred at 55° C. for 5 h. The solvent was removed in vacuo to obtain the product as a solid. The oil was triturated with diethyl ether (4 mL) to obtain the title product as a white solid. (19 mg, 73%): MS; m/z 390 (M+H): LCMS (UV) 90%; 1H NMR (400 MHz, DMSO-d6) δ 1.5-1.54 (m, 1H), 1.77-1.79 (m, 4H), 1.95-1.98 (m, 1H) 2.79-2.84 (m, 2H), 3.05-3.1 (m, 1H), 3.37-3.47 (m, 3H), 3.64-3.69 (m, 1H), 4.27-4.29 (m, 2H), 6.94 (d, 2H, J=9.2 Hz), 7.04-7.06 (m, 4H), 7.4 (d, 2H J=8.8 Hz)

1. customThe solvent was removed in vacuo