反应详情

To the product from step 1 (1.64 g, 4.1 mmol) was added 4M HCl in dioxane (45 mL) and the resulting mixture was stirred at rt for 5 h. The solvent was removed in vacuo to obtain the title product (1.38 g, 99%) 1H NMR (400 MHz, DMSO-d6) δ 1.67-2.15 (m, 5H), 3.17-3.21 (m, 2H), 3.88 (s, 2H), 4.07-4.12 (dd, 1H J1=8.4 Hz, J2=10.8 Hz), 4.18-4.22 (dd, 1H J1=3.6 Hz, J2=10.8 Hz), 6.91 (d, 2H, J=8.8 Hz), 7.16 (d, 2H, J=8.8 Hz), 7.22 (d, 2H, J=8.8 Hz); 7.33 (d, 2H, J=8.8 Hz)

1. customThe solvent was removed in vacuo