O-Butylhydroxylamine → 2-Butoxy-6-chloro-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid

HRID 750181Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 750181
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=O)[O:7][C:6]([C:13]([OH:15])=[O:14])=[C:5]2[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.[CH2:22]([O:26][NH2:27])[CH2:23][CH2:24][CH3:25]>C(O)C>[CH2:22]([O:26][N:27]1[C:6]([C:13]([OH:15])=[O:14])=[C:5]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:4]2[C:9](=[CH:10][CH:11]=[C:2]([Cl:1])[CH:3]=2)[C:8]1=[O:7])[CH2:23][CH2:24][CH3:25]

Komponenten

4

Edukt 2

HCID 3014370O-ButylhydroxylamineHCID 103800926-chloro-4-phenylisocoumarin-3-carboxylic Acid

Produkt 1

HCID 230609102-Butoxy-6-chloro-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 6-chloro-1-oxo-4-phenyl-1H-isochromen-3-carboxylic acid (210 mg), O-n-butylhydroxylamine (620 mg) and ethanol (8.4 ml) was stirred for 12 hrs. at 90° C. in a sealed tube. After cooling, the reaction mixture was concentrated under reduced pressure to give 2-butoxy-6-chloro-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid.

Aufarbeitung

  1. customat 90° C.
  2. temperatureAfter cooling
  3. concentrationthe reaction mixture was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-84f14ca441a34c329d8a47443748746a
Quelldatensatz
uspto-grants-2008_07
Patentnummer
US07402595B2

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