HuagongsheHuagongshe Chemistry Print Report · For research reference only
O-Butylhydroxylamine → 2-Butoxy-6-chloro-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | O-Butylhydroxylamine | HCID 3014370 | — |
| Reactant | 6-chloro-4-phenylisocoumarin-3-carboxylic Acid | HCID 10380092 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-Butoxy-6-chloro-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid | HCID 23060910 | — |
Reaction Steps
A mixture of 6-chloro-1-oxo-4-phenyl-1H-isochromen-3-carboxylic acid (210 mg), O-n-butylhydroxylamine (620 mg) and ethanol (8.4 ml) was stirred for 12 hrs. at 90° C. in a sealed tube. After cooling, the reaction mixture was concentrated under reduced pressure to give 2-butoxy-6-chloro-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07402595B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-84f14ca441a34c329d8a47443748746a |
| Source note | uspto-grants-2008_07 |