O-Butylhydroxylamine → 6-chloro-1-oxo-4-phenyl-2-propoxy-1,2-dihydroisoquinoline-3-carboxylic Acid

HRID 750184Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])O[C:6]([C:13]([OH:15])=[O:14])=[C:5]2[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.[CH2:22]([O:26][NH2:27])[CH2:23][CH2:24]C>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[N:27]([O:26][CH2:22][CH2:23][CH3:24])[C:6]([C:13]([OH:15])=[O:14])=[C:5]2[C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1

Participants

Reactant 2

HCID 3014370O-Butylhydroxylamine

HCID 103800926-chloro-4-phenylisocoumarin-3-carboxylic Acid

Product 1

HCID 230605466-chloro-1-oxo-4-phenyl-2-propoxy-1,2-dihydroisoquinoline-3-carboxylic Acid

Procedure

The present compound was synthesized by a method similar to that in Example 187 and using 6-chloro-1-oxo-4-phenyl-1H-isochromen-3-carboxylic acid and O-n-butylhydroxylamine. A colorless powder (280 mg).

Workup

customThe present compound was synthesized by a method similar to that in Example 187

Sources & evidence

ORD record: ord-8efb77aab97343f8b5b773e3b368bfc1
Source dataset: uspto-grants-2008_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07402595B2

Reaction notes

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