4-Methyl-5-(2-hydroxyethyl)thiazole → HCID 69156340, compound

HRID 750193Notes

Reaction equation

HRID 750193 reaction equation
C(O[C:9]([N:11](C)[N:12]1[C:21]([C:22](O)=[O:23])=[C:20]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:19]2[C:14](=[CH:15][CH:16]=[C:17]([Cl:31])[CH:18]=2)[C:13]1=[O:32])=O)C1C=CC=CC=1.[CH3:34][C:35]1[N:36]=[CH:37][S:38][C:39]=1[CH2:40][CH2:41][OH:42]>>[CH3:34][C:35]1[N:36]=[CH:37][S:38][C:39]=1[CH2:40][CH2:41][O:42][C:22]([C:21]1[N:12]([NH:11][CH3:9])[C:13](=[O:32])[C:14]2[C:19]([C:20]=1[C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1)=[CH:18][C:17]([Cl:31])=[CH:16][CH:15]=2)=[O:23]

Participants

3

Reactant 2

HCID 11364-Methyl-5-(2-hydroxyethyl)thiazoleHCID 691557392-[(benzyloxycarbonyl)(methyl)amino]-6-chloro-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic Acid

Product 1

HCID 69156340HCID 69156340, compound

Procedure

The present compound was synthesized by a method similar to that in Example 207 and using 2-[(benzyloxycarbonyl)(methyl)amino]-6-chloro-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid (150 mg) and 2-(4-methylthiazol-5-yl)ethanol. A colorless powder (41 mg).

Workup

  1. customThe present compound was synthesized by a method similar to that in Example 207

Sources & evidence

ORD record
ord-74c0b35f354a47aaa3b33137c7d1ab6e
Source dataset
uspto-grants-2008_07
Patent number
US07402595B2

Reaction notes

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