HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methoxybenzyl alcohol → 2-[(benzyloxycarbonyl)(methyl)amino]-6-chloro-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic Acid 4-methoxybenzyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methoxybenzyl alcohol | HCID 7738 | — |
| Reactant | 2-[(benzyloxycarbonyl)(methyl)amino]-6-chloro-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic Acid | HCID 69155739 | — |
| Product | 2-[(benzyloxycarbonyl)(methyl)amino]-6-chloro-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic Acid 4-methoxybenzyl Ester | HCID 69157233 | — |
Reaction Steps
The present compound was synthesized by a method similar to that in Example 200 and using 2-[(benzyloxycarbonyl)(methyl)amino]-6-chloro-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid (200 mg) and 4-methoxybenzyl alcohol. A colorless powder (110 mg). HPLC analysis (Agilent 1100 system): purity 96% (retention time: 4.30 min). MS (ESI+): 583 (M+H), 585.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07402595B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-fb8124114b03433ebe5983089b05bae5 |
| Source note | uspto-grants-2008_07 |