Acetic Acid Mixture with Hydrobromic Acid → HCID 10127499, compound

HRID 750217Notes

Reaction equation

HRID 750217 reaction equation
Br.C(O)(=O)C.C(OC(=O)[NH:15][C:16]1[N:17]([CH2:34][C:35]2[CH:43]=[CH:42][C:38]3[O:39][CH2:40][O:41][C:37]=3[CH:36]=2)[C:18](=[O:33])[C:19]2[C:24]([C:25]=1[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)=[CH:23][C:22]([Br:32])=[CH:21][CH:20]=2)C1C=CC=CC=1>>[NH2:15][C:16]1[N:17]([CH2:34][C:35]2[CH:43]=[CH:42][C:38]3[O:39][CH2:40][O:41][C:37]=3[CH:36]=2)[C:18](=[O:33])[C:19]2[C:24]([C:25]=1[C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1)=[CH:23][C:22]([Br:32])=[CH:21][CH:20]=2

Participants

3

Reactant 2

HCID 21893785Acetic Acid Mixture with Hydrobromic AcidHCID 69156334HCID 69156334, compound

Product 1

HCID 10127499HCID 10127499, compoundYield 119%

Procedure

25% Hydrogen bromide-acetic acid solution (10.0 ml) was added to [2-(benzo[1,3]dioxol-5-ylmethyl)-6-bromo-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl]carbamic acid benzyl ester (3.6 g), and the mixture was stirred at room temperature for 1 hr. The precipitate was collected by filtration, washed with diethyl ether and dried to give the title compound (3.3 g) as a colorless powder.

Workup

  1. filtrationThe precipitate was collected by filtration
  2. washwashed with diethyl ether
  3. customdried

Sources & evidence

ORD record
ord-62023e148bf14500af9d48e3a243384c
Source dataset
uspto-grants-2008_07
Patent number
US07402595B2

Reaction notes

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