Piperidine → HCID 23060951, compound

HRID 750222Notes

Reaction equation

HRID 750222 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][N:11]3[C:20]([C:21]([OH:23])=O)=[C:19]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)[C:18]4[C:13](=[CH:14][CH:15]=[C:16]([Br:30])[CH:17]=4)[C:12]3=[O:31])=[CH:9][C:4]=2[O:3][CH2:2]1.[NH:32]1[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]1>>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][N:11]3[C:20]([C:21]([N:32]4[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]4)=[O:23])=[C:19]([C:24]4[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=4)[C:18]4[C:13](=[CH:14][CH:15]=[C:16]([Br:30])[CH:17]=4)[C:12]3=[O:31])=[CH:9][C:4]=2[O:3][CH2:2]1

Participants

3

Reactant 2

HCID 8082PiperidineHCID 23060580HCID 23060580, compound

Product 1

HCID 23060951HCID 23060951, compound

Procedure

The present compound was synthesized by a method similar to that in Example 249 and using 2-(benzo[1,3]dioxol-5-ylmethyl)-6-bromo-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid (200 mg) and piperidine. Colorless crystals (150 mg).

Workup

  1. customThe present compound was synthesized by a method similar to that in Example 249

Sources & evidence

ORD record
ord-801e9bf965174e2eb0e696690a3942df
Source dataset
uspto-grants-2008_07
Patent number
US07402595B2

Reaction notes

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