3-Chloro-4-fluorophenylboronic Acid (contains varying amounts of Anhydride) → 2-benzyl-6-chloro-4-(3-chloro-4-fluorophenyl)-1-oxo-1,2-dihydroisoquinoline-3-carboxylic Acid Methyl Ester

HRID 750241Notes

Reaction equation

HRID 750241 reaction equation
[CH3:1][O:2][C:3]([C:5]1[N:6]([CH2:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[C:7](=[O:24])[C:8]2[C:13]([C:14]=1OS(C(F)(F)F)(=O)=O)=[CH:12][C:11]([Cl:23])=[CH:10][CH:9]=2)=[O:4].[Cl:32][C:33]1[CH:34]=[C:35](B(O)O)[CH:36]=[CH:37][C:38]=1[F:39]>>[CH3:1][O:2][C:3]([C:5]1[N:6]([CH2:25][C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=2)[C:7](=[O:24])[C:8]2[C:13]([C:14]=1[C:35]1[CH:36]=[CH:37][C:38]([F:39])=[C:33]([Cl:32])[CH:34]=1)=[CH:12][C:11]([Cl:23])=[CH:10][CH:9]=2)=[O:4]

Participants

3

Reactant 2

HCID 27346603-Chloro-4-fluorophenylboronic Acid (contains varying amounts of Anhydride)HCID 865995572-Benzyl-6-chloro-1-oxo-4-trifluoromethanesulfonyloxy-1,2-dihydroisoquinoline-3-carboxylic acid methyl ester

Product 1

HCID 691566172-benzyl-6-chloro-4-(3-chloro-4-fluorophenyl)-1-oxo-1,2-dihydroisoquinoline-3-carboxylic Acid Methyl Ester

Procedure

The present compound was synthesized by a method similar to that in Example 272 and using 2-benzyl-6-chloro-1-oxo-4-trifluoromethanesulfonyloxy-1,2-dihydroisoquinoline-3-carboxylic acid methyl ester (100 mg) and 3-chloro-4-fluorophenylboronic acid. A colorless powder (80 mg).

Workup

  1. customThe present compound was synthesized by a method similar to that in Example 272

Sources & evidence

ORD record
ord-91180151d1834bfa81ee791c62d16c5e
Source dataset
uspto-grants-2008_07
Patent number
US07402595B2

Reaction notes

Loading…