HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloro-4-fluorophenylboronic Acid (contains varying amounts of Anhydride) → 2-benzyl-6-chloro-4-(3-chloro-4-fluorophenyl)-1-oxo-1,2-dihydroisoquinoline-3-carboxylic Acid Methyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloro-4-fluorophenylboronic Acid (contains varying amounts of Anhydride) | HCID 2734660 | — |
| Reactant | 2-Benzyl-6-chloro-1-oxo-4-trifluoromethanesulfonyloxy-1,2-dihydroisoquinoline-3-carboxylic acid methyl ester | HCID 86599557 | — |
| Product | 2-benzyl-6-chloro-4-(3-chloro-4-fluorophenyl)-1-oxo-1,2-dihydroisoquinoline-3-carboxylic Acid Methyl Ester | HCID 69156617 | — |
Reaction Steps
The present compound was synthesized by a method similar to that in Example 272 and using 2-benzyl-6-chloro-1-oxo-4-trifluoromethanesulfonyloxy-1,2-dihydroisoquinoline-3-carboxylic acid methyl ester (100 mg) and 3-chloro-4-fluorophenylboronic acid. A colorless powder (80 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07402595B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-91180151d1834bfa81ee791c62d16c5e |
| Source note | uspto-grants-2008_07 |