3-Formylphenylboronic acid → HCID 86599559, compound

HRID 750246Notes

Reaction equation

HRID 750246 reaction equation
[CH3:1][O:2][C:3]([C:5]1[N:6]([CH2:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[C:7](=[O:24])[C:8]2[C:13]([C:14]=1OS(C(F)(F)F)(=O)=O)=[CH:12][C:11]([Cl:23])=[CH:10][CH:9]=2)=[O:4].[CH:32]([C:34]1[CH:35]=[C:36](B(O)O)[CH:37]=[CH:38][CH:39]=1)=[O:33]>>[CH3:1][O:2][C:3]([C:5]1[N:6]([CH2:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[C:7](=[O:24])[C:8]2[C:13]([C:14]=1[C:38]1[CH:37]=[CH:36][CH:35]=[C:34]([CH:32]=[O:33])[CH:39]=1)=[CH:12][C:11]([Cl:23])=[CH:10][CH:9]=2)=[O:4]

Participants

3

Reactant 2

HCID 27343563-Formylphenylboronic acidHCID 865995572-Benzyl-6-chloro-1-oxo-4-trifluoromethanesulfonyloxy-1,2-dihydroisoquinoline-3-carboxylic acid methyl ester

Product 1

HCID 86599559HCID 86599559, compound

Procedure

The present compound was synthesized by a method similar to that in Example 272 and using 2-benzyl-6-chloro-1-oxo-4-trifluoromethanesulfonyloxy-1,2-dihydroisoquinoline-3-carboxylic acid methyl ester (300 mg) and 3-formylphenylboronic acid. Colorless crystals (140 mg).

Workup

  1. customThe present compound was synthesized by a method similar to that in Example 272

Sources & evidence

ORD record
ord-69698913851649d3a13b795cb7021125
Source dataset
uspto-grants-2008_07
Patent number
US07402595B2

Reaction notes

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