4-Hydroxymethylpyridin-2-carboxylic acid isobutyl ester → 2-benzyl-6-bromo-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic Acid 2-isobutoxycarbonylpyridin-4-ylmethyl Ester

HRID 750249Notes

Reaction equation

HRID 750249 reaction equation
[CH2:1]([N:8]1[C:17]([C:18]([OH:20])=[O:19])=[C:16]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([Br:27])[CH:14]=2)[C:9]1=[O:28])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:29]([O:33][C:34]([C:36]1[CH:41]=[C:40]([CH2:42]O)[CH:39]=[CH:38][N:37]=1)=[O:35])[CH:30]([CH3:32])[CH3:31]>>[CH2:29]([O:33][C:34]([C:36]1[CH:41]=[C:40]([CH2:42][O:19][C:18]([C:17]2[N:8]([CH2:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[C:9](=[O:28])[C:10]3[C:15]([C:16]=2[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)=[CH:14][C:13]([Br:27])=[CH:12][CH:11]=3)=[O:20])[CH:39]=[CH:38][N:37]=1)=[O:35])[CH:30]([CH3:32])[CH3:31]

Participants

3

Reactant 2

HCID 109217344-Hydroxymethylpyridin-2-carboxylic acid isobutyl esterHCID 230606482-benzyl-6-bromo-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic Acid

Product 1

HCID 691554132-benzyl-6-bromo-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic Acid 2-isobutoxycarbonylpyridin-4-ylmethyl Ester

Procedure

The present compound was synthesized by a method similar to that in Example 200 and using 2-benzyl-6-bromo-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid (600 mg) and 4-hydroxymethylpyridin-2-carboxylic acid isobutyl ester. A colorless powder (530 mg).

Workup

  1. customThe present compound was synthesized by a method similar to that in Example 200

Sources & evidence

ORD record
ord-f6c37ae98dae4d82a710e75c0a4611b6
Source dataset
uspto-grants-2008_07
Patent number
US07402595B2

Reaction notes

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