HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Hydroxymethylpyridin-2-carboxylic acid isobutyl ester → 2-benzyl-6-bromo-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic Acid 2-isobutoxycarbonylpyridin-4-ylmethyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Hydroxymethylpyridin-2-carboxylic acid isobutyl ester | HCID 10921734 | — |
| Reactant | 2-benzyl-6-bromo-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic Acid | HCID 23060648 | — |
| Product | 2-benzyl-6-bromo-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic Acid 2-isobutoxycarbonylpyridin-4-ylmethyl Ester | HCID 69155413 | — |
Reaction Steps
The present compound was synthesized by a method similar to that in Example 200 and using 2-benzyl-6-bromo-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid (600 mg) and 4-hydroxymethylpyridin-2-carboxylic acid isobutyl ester. A colorless powder (530 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07402595B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-f6c37ae98dae4d82a710e75c0a4611b6 |
| Source note | uspto-grants-2008_07 |