HRID750262

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID21866389

未命名化合物

结构：COC(=O)c1c(-c2ccccc2)c2cc(NCc3ccccc3)ccc2c(=O)n1Cc1ccc(C(=O)OC(C)(C)C)cc1

HCID69157344

未命名化合物

PRODUCTS

生成物

结构：COC(=O)c1c(-c2ccccc2)c2cc(NCc3ccccc3)ccc2c(=O)n1Cc1ccc(C(=O)O)cc1.Cl

HCID69155573

未命名化合物

PROCEDURE

实验过程

To 4N-hydrochloric acid ethyl acetate solution (6 ml) was added 6-benzylamino-2-(4-tert-butoxycarbonylbenzyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid methyl ester (300 mg), and the mixture was stirred at room temperature for 6 hrs. Crystals were collected by filtration to give the title compound (260 mg).

WORKUP

后处理

filtrationCrystals were collected by filtration

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3b35413b6d6b4091b0603d17793db017
来源数据集: uspto-grants-2008_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07402595B2
来源说明: uspto-grants-2008_07

反应 SMILES

C(OC(=O)C)C.[ClH:7].[CH3:8][O:9][C:10]([C:12]1[N:13]([CH2:37][C:38]2[CH:43]=[CH:42][C:41]([C:44]([O:46]C(C)(C)C)=[O:45])=[CH:40][CH:39]=2)[C:14](=[O:36])[C:15]2[C:20]([C:21]=1[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[CH:19][C:18]([NH:28][CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)=[CH:17][CH:16]=2)=[O:11]>>[ClH:7].[CH3:8][O:9][C:10]([C:12]1[N:13]([CH2:37][C:38]2[CH:39]=[CH:40][C:41]([C:44]([OH:46])=[O:45])=[CH:42][CH:43]=2)[C:14](=[O:36])[C:15]2[C:20]([C:21]=1[C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1)=[CH:19][C:18]([NH:28][CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)=[CH:17][CH:16]=2)=[O:11]