Hydrogen chloride-ethyl acetate → 6-benzylamino-2-(4-carboxybenzyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic Acid Methyl Ester Hydrochloride

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Reaction Steps

To 4N-hydrochloric acid ethyl acetate solution (6 ml) was added 6-benzylamino-2-(4-tert-butoxycarbonylbenzyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid methyl ester (300 mg), and the mixture was stirred at room temperature for 6 hrs. Crystals were collected by filtration to give the title compound (260 mg).

Provenance & Evidence