HCID 9958506, compound → HCID 44451793, compound

HRID 750288Notes

Reaction equation

HRID 750288 reaction equation
[CH3:1][O:2][C:3]([C:5]1[N:6]([CH2:23][C:24]2[CH:29]=[CH:28][C:27]([S:30]([CH3:33])(=[O:32])=[O:31])=[CH:26][CH:25]=2)[C:7](=[O:22])[C:8]2[C:13]([C:14]=1[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[CH:12][C:11](Br)=[CH:10][CH:9]=2)=[O:4]>[C].[Pd].CO>[CH3:1][O:2][C:3]([C:5]1[N:6]([CH2:23][C:24]2[CH:25]=[CH:26][C:27]([S:30]([CH3:33])(=[O:32])=[O:31])=[CH:28][CH:29]=2)[C:7](=[O:22])[C:8]2[C:13]([C:14]=1[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:4]

Participants

4

Reactant 1

HCID 9958506HCID 9958506, compound

Product 1

HCID 44451793HCID 44451793, compoundYield 74.7%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

A mixture of 6-bromo-2-(4-methanesulfonylbenzyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid methyl ester (200 mg) obtained in Example 94, 10% palladium carbon (20 mg) and methanol (4 ml) was stirred under a hydrogen atmosphere for 1 hr. The catalyst was removed by filtration, and the filtrate was concentrated under reduced pressure to give the title compound (127 mg) as a colorless powder.

Workup

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-2fa78f2a816b48d5a427cc7aafa4077d
Source dataset
uspto-grants-2008_07
Patent number
US07402595B2

Reaction notes

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