反应详情

To a solution of 6-bromo-2-(4-carboxybenzyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid methyl ester (4.9 g) in tetrahydrofuran (20 ml) was added a solution (1M, 30 ml) of borane in tetrahydrofuran, and the mixture was stirred at room temperature for 3 hr. The solvent was evaporated under reduced pressure, 1N hydrochloric acid was added, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine and dried by adding sodium sulfate. The solvent was evaporated under reduced pressure and the obtained residue was purified by recrystallization from methanol to give the title compound (2.97 g, 62%).

1. customThe solvent was evaporated under reduced pressure, 1N hydrochloric acid
2. additionwas added
3. extractionthe mixture was extracted with ethyl acetate
4. washThe extract was washed with saturated brine
5. customdried
6. additionby adding sodium sulfate
7. customThe solvent was evaporated under reduced pressure
8. customthe obtained residue was purified by recrystallization from methanol