Methanesulfonate → HCID 23060531, compound

HRID 750319Notes

Reaction equation

HRID 750319 reaction equation
[C:1]([C:4]1[N:5]([CH2:22][C:23]2[CH:28]=[CH:27][C:26]([CH2:29]O)=[CH:25][CH:24]=2)[C:6](=[O:21])[C:7]2[C:12]([C:13]=1[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[CH:11][C:10]([Br:20])=[CH:9][CH:8]=2)(=[O:3])[CH3:2].[S:31]([O-])(=O)(=O)[CH3:32].C[S-].[Na+]>>[C:1]([C:4]1[N:5]([CH2:22][C:23]2[CH:28]=[CH:27][C:26]([CH2:29][S:31][CH3:32])=[CH:25][CH:24]=2)[C:6](=[O:21])[C:7]2[C:12]([C:13]=1[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[CH:11][C:10]([Br:20])=[CH:9][CH:8]=2)(=[O:3])[CH3:2]

Participants

4

Reactant 3

HCID 85257MethanesulfonateHCID 4378561Sodium methanethiolateHCID 23060581HCID 23060581, compound

Product 1

HCID 23060531HCID 23060531, compoundYield 64%

Procedure

By a method similar to that in Example 395, 3-acetyl-6-bromo-2-(4-hydroxymethylbenzyl)-4-phenyl-2H-isoquinolin-1-one was converted to mesylate and reacted with sodium thiomethoxide to give the title compound (239 mg, 64%).

Sources & evidence

ORD record
ord-52038a8df00042028f039c1360c4b3aa
Source dataset
uspto-grants-2008_07
Patent number
US07402595B2

Reaction notes

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