HRID750323

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID70770

Ethyl 4-piperidinecarboxylate

C8H15NO2

反应SMILES：CC(=O)c1c(-c2ccccc2)c2cc(Br)ccc2c(=O)n1Cc1ccc(C(=O)O)cc1

HCID69156310

未命名化合物

PRODUCTS

产物

反应SMILES：CCOC(=O)C1CCN(C(=O)c2ccc(Cn3c(C(C)=O)c(-c4ccccc4)c4cc(Br)ccc4c3=O)cc2)CC1

HCID69156417

未命名化合物

PROCEDURE

实验过程

In the same manner as in Example 423, the title compound was synthesized from 4-(3-acetyl-6-bromo-1-oxo-4-phenyl-1H-isoquinolin-2-ylmethyl)benzoic acid and piperidine-4-carboxylic acid ethyl ester.

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-bc22d4aade104d3aace64b6018ff66d8
来源数据集: uspto-grants-2008_07
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US07402595B2
来源说明: uspto-grants-2008_07

反应SMILES

[C:1]([C:4]1[N:5]([CH2:22][C:23]2[CH:31]=[CH:30][C:26]([C:27](O)=[O:28])=[CH:25][CH:24]=2)[C:6](=[O:21])[C:7]2[C:12]([C:13]=1[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[CH:11][C:10]([Br:20])=[CH:9][CH:8]=2)(=[O:3])[CH3:2].[CH2:32]([O:34][C:35]([CH:37]1[CH2:42][CH2:41][NH:40][CH2:39][CH2:38]1)=[O:36])[CH3:33]>>[CH2:32]([O:34][C:35]([CH:37]1[CH2:42][CH2:41][N:40]([C:27](=[O:28])[C:26]2[CH:30]=[CH:31][C:23]([CH2:22][N:5]3[C:4]([C:1](=[O:3])[CH3:2])=[C:13]([C:14]4[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=4)[C:12]4[C:7](=[CH:8][CH:9]=[C:10]([Br:20])[CH:11]=4)[C:6]3=[O:21])=[CH:24][CH:25]=2)[CH2:39][CH2:38]1)=[O:36])[CH3:33]