Ethyl 4-piperidinecarboxylate → 1-[4-(3-acetyl-6-bromo-1-oxo-4-phenyl-1H-isoquinolin-2-ylmethyl)benzoyl]piperidine-4-carboxylic Acid Ethyl Ester

HRID 750323Notes

Reaction equation

HRID 750323 reaction equation
[C:1]([C:4]1[N:5]([CH2:22][C:23]2[CH:31]=[CH:30][C:26]([C:27](O)=[O:28])=[CH:25][CH:24]=2)[C:6](=[O:21])[C:7]2[C:12]([C:13]=1[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[CH:11][C:10]([Br:20])=[CH:9][CH:8]=2)(=[O:3])[CH3:2].[CH2:32]([O:34][C:35]([CH:37]1[CH2:42][CH2:41][NH:40][CH2:39][CH2:38]1)=[O:36])[CH3:33]>>[CH2:32]([O:34][C:35]([CH:37]1[CH2:42][CH2:41][N:40]([C:27](=[O:28])[C:26]2[CH:30]=[CH:31][C:23]([CH2:22][N:5]3[C:4]([C:1](=[O:3])[CH3:2])=[C:13]([C:14]4[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=4)[C:12]4[C:7](=[CH:8][CH:9]=[C:10]([Br:20])[CH:11]=4)[C:6]3=[O:21])=[CH:24][CH:25]=2)[CH2:39][CH2:38]1)=[O:36])[CH3:33]

Participants

3

Reactant 2

HCID 70770Ethyl 4-piperidinecarboxylateHCID 691563104-(3-acetyl-6-bromo-1-oxo-4-phenyl-1H-isoquinolin-2-ylmethyl)benzoic Acid

Product 1

HCID 691564171-[4-(3-acetyl-6-bromo-1-oxo-4-phenyl-1H-isoquinolin-2-ylmethyl)benzoyl]piperidine-4-carboxylic Acid Ethyl Ester

Procedure

In the same manner as in Example 423, the title compound was synthesized from 4-(3-acetyl-6-bromo-1-oxo-4-phenyl-1H-isoquinolin-2-ylmethyl)benzoic acid and piperidine-4-carboxylic acid ethyl ester.

Sources & evidence

ORD record
ord-bc22d4aade104d3aace64b6018ff66d8
Source dataset
uspto-grants-2008_07
Patent number
US07402595B2

Reaction notes

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