Hydrogen chloride-ethyl acetate → HCID 23060587, compound

HRID 750325Notes

Reaction equation

HRID 750325 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][N:16]2[C:25]([C:26](=[O:28])[CH3:27])=[C:24]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[C:23]3[C:18](=[CH:19][CH:20]=[C:21]([Br:35])[CH:22]=3)[C:17]2=[O:36])=[CH:11][CH:10]=1)(C)(C)C.C(OC(=O)C)C.[ClH:44]>>[ClH:44].[C:26]([C:25]1[N:16]([CH2:15][C:12]2[CH:11]=[CH:10][C:9]([CH2:8][NH2:7])=[CH:14][CH:13]=2)[C:17](=[O:36])[C:18]2[C:23]([C:24]=1[C:29]1[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=1)=[CH:22][C:21]([Br:35])=[CH:20][CH:19]=2)(=[O:28])[CH3:27]

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 69157281HCID 69157281, compound

Product 1

HCID 23060587HCID 23060587, compoundYield 82%

Procedure

To [4-(3-acetyl-6-bromo-1-oxo-4-phenyl-1H-isoquinolin-2-ylmethyl)benzyl]carbamic acid tert-butyl ester (561 mg) was added 4N hydrochloric acid ethyl acetate solution (5 ml) and the mixture was stirred at room temperature for 30 min. The solvent was evaporated under reduced pressure and toluene was added. The solvent was evaporated again under reduced pressure. To the obtained residue was added diisopropyl ether and the mixture was crystallized to give the title compound (410 mg, 82%).

Workup

  1. customThe solvent was evaporated under reduced pressure and toluene
  2. additionwas added
  3. customThe solvent was evaporated again under reduced pressure
  4. additionTo the obtained residue was added diisopropyl ether
  5. customthe mixture was crystallized

Sources & evidence

ORD record
ord-dc2ca9a573404565be690c89000824e4
Source dataset
uspto-grants-2008_07
Patent number
US07402595B2

Reaction notes

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