2-Benzoyl-4-chlorobenzoic acid → 4-(6-chloro-3-butyryl-1-oxo-4-phenyl-1H-isoquinolin-2-ylmethyl)benzenesulfonamide

HRID 750333Notes

Reaction equation

HRID 750333 reaction equation
Cl.[OH:2][CH:3]([CH2:17][CH2:18][CH3:19])[CH2:4][NH:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([S:13]([NH2:16])(=[O:15])=[O:14])=[CH:9][CH:8]=1.[C:20]([C:28]1[CH:36]=[C:35]([Cl:37])[CH:34]=[CH:33][C:29]=1[C:30](O)=[O:31])(=O)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[Cl:37][C:35]1[CH:36]=[C:28]2[C:29](=[CH:33][CH:34]=1)[C:30](=[O:31])[N:5]([CH2:6][C:7]1[CH:8]=[CH:9][C:10]([S:13]([NH2:16])(=[O:14])=[O:15])=[CH:11][CH:12]=1)[C:4]([C:3](=[O:2])[CH2:17][CH2:18][CH3:19])=[C:20]2[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 122052902-Benzoyl-4-chlorobenzoic acidHCID 691577614-[(2-hydroxypentylamino)methyl]benzenesulfonamide Hydrochloride

Product 1

HCID 101522654-(6-chloro-3-butyryl-1-oxo-4-phenyl-1H-isoquinolin-2-ylmethyl)benzenesulfonamide

Procedure

In the same manner as in Example 452, Step 2, the title compound was synthesized from 4-[(2-hydroxypentylamino)methyl]benzenesulfonamide hydrochloride and 2-benzoyl-4-chlorobenzoic acid.

Sources & evidence

ORD record
ord-8312ea5defa7454aa685ab7891abf782
Source dataset
uspto-grants-2008_07
Patent number
US07402595B2

Reaction notes

Loading…