2-Benzoyl-4-chlorobenzoic acid → 4-(6-chloro-1-oxo-4-phenyl-3-propionyl-1H-isoquinolin-2-ylmethyl)benzoic Acid Methyl Ester

HRID 750337Notes

Reaction equation

HRID 750337 reaction equation
Cl.[CH3:2][O:3][C:4](=[O:18])[C:5]1[CH:10]=[CH:9][C:8]([CH2:11][NH:12][CH2:13][CH:14]([OH:17])[CH2:15][CH3:16])=[CH:7][CH:6]=1.[C:19]([C:27]1[CH:35]=[C:34]([Cl:36])[CH:33]=[CH:32][C:28]=1[C:29](O)=[O:30])(=O)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>>[CH3:2][O:3][C:4](=[O:18])[C:5]1[CH:6]=[CH:7][C:8]([CH2:11][N:12]2[C:13]([C:14](=[O:17])[CH2:15][CH3:16])=[C:19]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[C:27]3[C:28](=[CH:32][CH:33]=[C:34]([Cl:36])[CH:35]=3)[C:29]2=[O:30])=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 122052902-Benzoyl-4-chlorobenzoic acidHCID 691570244-[(2-Hydroxybutylamino)methyl]benzoic acid methyl ester hydrochloride

Product 1

HCID 691571444-(6-chloro-1-oxo-4-phenyl-3-propionyl-1H-isoquinolin-2-ylmethyl)benzoic Acid Methyl Ester

Procedure

In the same manner as in Example 458, Step 2, the title compound was synthesized from 4-[(2-hydroxybutylamino)methyl]benzoic acid methyl ester hydrochloride and 2-benzoyl-4-chlorobenzoic acid.

Sources & evidence

ORD record
ord-96ab53c317754273a77f5a916cb0f8cb
Source dataset
uspto-grants-2008_07
Patent number
US07402595B2

Reaction notes

Loading…