反应详情

To a solution of bicyclo[2.2.1]hept-5-ene-3-carboxylic acid (25.0 mL, 204.3 mmol) in NaHCO3 (51.5 g, 612.9 mmol) in water was added bromine (32.7 g, 204.3 mmol) dropwise at 0° C. The solution was stirred for 1 hour and extracted with ether, and the organic phase was washed successively with 1 N Na2S2SO3 solution and brine, and the organic phase was then dried (Na2SO4), filtered and concentrated in vacuo to afford 30 g of crude product that was used without further purification.

1. extractionextracted with ether
2. washthe organic phase was washed successively with 1 N Na2S2SO3 solution and brine
3. dry with materialthe organic phase was then dried (Na2SO4)
4. filtrationfiltered
5. concentrationconcentrated in vacuo