3-Fluorobenzaldehyde → HCID 59753870, compound

HRID 750478Notes

Reaction equation

HRID 750478 reaction equation
Br[C:2]1[C:3]([Cl:9])=[N:4][C:5]([Cl:8])=[N:6][CH:7]=1.[F:10][C:11]1[CH:12]=[C:13]([CH:16]=[CH:17][CH:18]=1)[CH:14]=[O:15]>>[Cl:8][C:5]1[N:4]=[C:3]([Cl:9])[C:2]([CH:14]([C:13]2[CH:16]=[CH:17][CH:18]=[C:11]([F:10])[CH:12]=2)[OH:15])=[CH:7][N:6]=1

Participants

3

Reactant 2

HCID 680093-FluorobenzaldehydeHCID 2899735-Bromo-2,4-dichloropyrimidine

Product 1

HCID 59753870HCID 59753870, compoundYield 79%

Procedure

The compound was prepared from 5-bromo-2,4-dichloropyrimidine (Aldrich) and 3-fluorobenzaldehyde (Aldrich) in 79% yield in an analogous manner as described in Example 1. 1H NMR (300 MHz, CDCl3) δ 8.85 (s, 1H), 7.35 (m, 1H), 7.14 (m, 3H), 7.14 (m, 3H), 6.077 (s, 1H).

Sources & evidence

ORD record
ord-c174a9d949804ab9a9788be11e3ab0fe
Source dataset
uspto-grants-2008_07
Patent number
US07405220B2

Reaction notes

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