反应详情

温度

-78 °C

To a stirred solution of 2,4-dichloro-pyrimidine-5-carbaldehyde (Example 17, 1.01 g, 5.7 mmol) in THF (10 mL), methyl magnesium bromide (Aldrich, 3 M in ether, 6.27 mmol, 2.1 mL) was added slowly at −78° C. The mixture was stirred for an additional 2 hours at −78° C. and the reaction was quenched with 1N HCl (10 mL). The resulting mixture was extracted with EtOAc and the extract was dried with sodium sulfate. Removal of solvent gave a brown solid. 1.07 g, 97%. MS (M+H)+, 193.

1. customthe reaction was quenched with 1N HCl (10 mL)
2. extractionThe resulting mixture was extracted with EtOAc
3. dry with materialthe extract was dried with sodium sulfate
4. customRemoval of solvent
5. customgave a brown solid