Hydrazine → HCID 178434464, compound

HRID 750486Notes

Reaction equation

HRID 750486 reaction equation
[NH2:1][NH2:2].[Cl:3][C:4]1[N:9]=[C:8](Cl)[C:7]([C:11](=O)[CH3:12])=[CH:6][N:5]=1>C1COCC1>[Cl:3][C:4]1[N:9]=[C:8]2[NH:1][N:2]=[C:11]([CH3:12])[C:7]2=[CH:6][N:5]=1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 212747081-(2,4-Dichloropyrimidin-5-yl)ethan-1-one

Product 1

HCID 178434464HCID 178434464, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a stirred solution of hydrazine (Aldrich, 102.4 mg, 3.2 mmol) in THF (5 mL), 1-(2,4-dichloro-pyrimidin-5-yl)-ethanone (Example 21, 191 mg, 1 mmol) was added and the mixture was stirred at room temperature for 1 hour. The reaction was quenched with water (5 mL) and the mixture was extracted with EtOAc/THF(3×5 mL, 1:1 mixture of EtOAc:THF ). The extract was dried with sodium sulfate and concentrated to give a solid. 126 mg, 75%. MS (M+H)+, 169.

Workup

  1. customThe reaction was quenched with water (5 mL)
  2. extractionthe mixture was extracted with EtOAc/THF(3×5 mL, 1:1 mixture of EtOAc:THF )
  3. dry with materialThe extract was dried with sodium sulfate
  4. concentrationconcentrated
  5. customto give a solid

Sources & evidence

ORD record
ord-cd85f807f6cd471390676b6fb7a364c6
Source dataset
uspto-grants-2008_07
Patent number
US07405220B2

Reaction notes

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