反应详情

To a stirred solution of hydrazine (Aldrich, 102.4 mg, 3.2 mmol) in THF (5 mL), 1-(2,4-dichloro-pyrimidin-5-yl)-ethanone (Example 21, 191 mg, 1 mmol) was added and the mixture was stirred at room temperature for 1 hour. The reaction was quenched with water (5 mL) and the mixture was extracted with EtOAc/THF(3×5 mL, 1:1 mixture of EtOAc:THF ). The extract was dried with sodium sulfate and concentrated to give a solid. 126 mg, 75%. MS (M+H)+, 169.

1. customThe reaction was quenched with water (5 mL)
2. extractionthe mixture was extracted with EtOAc/THF(3×5 mL, 1:1 mixture of EtOAc:THF )
3. dry with materialThe extract was dried with sodium sulfate
4. concentrationconcentrated
5. customto give a solid