[1-(Methylsulfonyl)piperidin-4-yl]amine trifluoroacetate → HCID 178504945, compound

HRID 750491Notes

Reaction equation

HRID 750491 reaction equation
Cl[C:2]1[N:7]=[C:6]2[NH:8][N:9]=[C:10]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[C:5]2=[CH:4][N:3]=1.FC(F)(F)C(O)=O.[CH3:24][S:25]([N:28]1[CH2:33][CH2:32][CH:31]([NH2:34])[CH2:30][CH2:29]1)(=[O:27])=[O:26]>>[CH3:24][S:25]([N:28]1[CH2:29][CH2:30][CH:31]([NH:34][C:2]2[N:7]=[C:6]3[NH:8][N:9]=[C:10]([C:11]4[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=4)[C:5]3=[CH:4][N:3]=2)[CH2:32][CH2:33]1)(=[O:27])=[O:26]

Participants

3

Reactant 2

HCID 11975076[1-(Methylsulfonyl)piperidin-4-yl]amine trifluoroacetateHCID 178478328HCID 178478328, compound

Product 1

HCID 178504945HCID 178504945, compoundYield 21%

Procedure

The compound was prepared from 6-chloro-3-phenyl-1H-pyrazolo[3,4-d]pyrimidine (Example 14) and 1-methanesulfonyl-piperidin-4-ylamine; compound with trifluoro-acetic acid in an analogous manner as described in Example 4 and was purified by HPLC (Gilson) to give a free base (21% yield). MS (M+H)+, 373.24.

Workup

  1. customwas purified by HPLC (Gilson)

Sources & evidence

ORD record
ord-25f8dfa3e484433dbe136023afb15cc4
Source dataset
uspto-grants-2008_07
Patent number
US07405220B2

Reaction notes

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