反应详情

温度

70 °C

The product of step b) (300 mg) was treated with 10 mL HOAc and 2 mL of 1 M NaOH. The suspension was heated to 70° C. for 4 h. The reaction was cooled and partitioned between EtOAc and water. The organic layer was dried over MgSO4 and concentrated to give 300 mg of the sub-title compound as a yellow oil. MS: ESI (negative): 422, 424 (M−H).

1. temperatureThe reaction was cooled
2. custompartitioned between EtOAc and water
3. dry with materialThe organic layer was dried over MgSO4
4. concentrationconcentrated