HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 750633Generated: October 26, 2026
Sodium Hydroxide → tert-butyl 2-(5-chloro-3-(4-hydroxyphthalazin-1-yl)-2-methyl-1H-indol-1-yl)acetate
https://huagongshe.com/reaction/750633
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | tert-Butyl 2-(5-chloro-3-(4-chlorophthalazin-1-yl)-2-methyl-1H-indol-1-yl)acetate | HCID 58247160 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | tert-butyl 2-(5-chloro-3-(4-hydroxyphthalazin-1-yl)-2-methyl-1H-indol-1-yl)acetate | HCID 58247168 | — |
Reaction Steps
The product of step b) (300 mg) was treated with 10 mL HOAc and 2 mL of 1 M NaOH. The suspension was heated to 70° C. for 4 h. The reaction was cooled and partitioned between EtOAc and water. The organic layer was dried over MgSO4 and concentrated to give 300 mg of the sub-title compound as a yellow oil. MS: ESI (negative): 422, 424 (M−H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07405215B2 |
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| Source dataset | uspto-grants-2008_07 |
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| ORD ID | ord-ae0c1f4fb04a49aca59fcad20964bda4 |
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| Source note | uspto-grants-2008_07 |
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