1-(Bromomethyl)-3-(trifluoromethyl)benzene → {3-[1,1-Dioxo-2-(3-trifluoromethyl-benzyl)-2,3-dihydro-1h-1lambda6-benzo[d]isothiazol-3-yl]-2-methyl-indol-1-yl}-acetic acid

HRID 750655노트

반응식

C([O:5][C:6](=[O:29])[CH2:7][N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:10]([CH:17]2[C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=3[S:19](=[O:27])(=[O:26])[NH:18]2)=[C:9]1[CH3:28])(C)(C)C.[F:30][C:31]([F:41])([F:40])[C:32]1[CH:33]=[C:34]([CH:37]=[CH:38][CH:39]=1)[CH2:35]Br>>[O:26]=[S:19]1(=[O:27])[C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[CH:17]([C:10]2[C:11]3[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=3)[N:8]([CH2:7][C:6]([OH:5])=[O:29])[C:9]=2[CH3:28])[N:18]1[CH2:35][C:34]1[CH:37]=[CH:38][CH:39]=[C:32]([C:31]([F:30])([F:40])[F:41])[CH:33]=1

참가 물질

반응물 2

HCID 1230611-(Bromomethyl)-3-(trifluoromethyl)benzene

HCID 67317115[3-(1,1-Dioxo-2,3-dihydro-1h-1lambda6-benzo[d]isothiazol-3-yl)-2-methyl-indol-1-yl]-acetic acid tert-butyl ester

생성물 1

HCID 59753801{3-[1,1-Dioxo-2-(3-trifluoromethyl-benzyl)-2,3-dihydro-1h-1lambda6-benzo[d]isothiazol-3-yl]-2-methyl-indol-1-yl}-acetic acid

실험 절차

The title compound was prepared by the method described for example 14 using the product from example 3, step c) and 3-trifluoromethyl-benzyl bromide. MS: ESI (negative): 513 (M−H).

출처 및 근거

ORD 기록: ord-39d35862ee7c490aaaf06d346175c089
출처 데이터셋: uspto-grants-2008_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07405215B2

반응 노트

불러오는 중…