反应详情

Suspended into 135 mL of toluene was 18.0 g of the carboxylic acid (26) obtained in Synthesis Example 1-1-2, and then into the resulting suspension was gradually added 10.3 g of oxalyl chloride at 80° C. After this mixture was stirred for 4 hours, toluene was removed by distillation under reduced pressure to obtain the intended product. The obtained acid chloride was used in the next reaction without further purification.

1. customobtained in Synthesis Example 1-1-2
2. customat 80° C
3. customtoluene was removed by distillation under reduced pressure
4. customto obtain the intended product