反应详情

2-Methylsulfonyl-4-(3-pyridyloxy)-5-(4-chlorophenyl)-6-(2,4-dichlorophenyl)pyrimidine from Example 86 (30 mg, 0.06 mmol) was reacted with 2 equivalents each of n-butyl lithium and neopentyl alcohol by the procedure described in Reference Examples 6 and 7 to afford 2-(2,2-dimethylpropyloxy)-4-(3-pyridyloxy)-5-(4-chlorophenyl)-6-(2,4-dichlorophenyl)pyrimidine: HPLC/MS: m/e=514 (M++1); Rt4.48 min. 1H-NMR400 MHz (CDCl3): δ 1.20-1.30 (s, 9H), 3.88 (s, 2H), 7.15-7.28 (m, 7H), 7.40-7.43 (m, 1H), 7.58-7.61 (m, 1H), 8.52-8.56 (m, 2H).