反应详情

2-Methylsulfonyl-4-(3-pyridyloxy)-5-(4-chlorophenyl)-6-(2,4-dichlorophenyl)pyrimidine from Example 86 (50 mg, 0.1 mmol) was reacted with 2 equivalents each of n-butyl lithium and n-propanol by the procedure described in Reference Examples 6 and 7 to afford 2-(2-n-propyloxy-4-(3-pyridyloxy)-5-(4-chlorophenyl)-6-(2,4-dichlorophenyl)pyrimidine. HPLC/MS: m/e=486 (M++1); Rt4.13 min. 1H-NMR 500 MHz (CDCl3): δ 0.96 (t, 3H), 1.73-1.79 (m, 2H), 4.13-4.18 (m, 2H), 7.18-7.30 (m, 7H), 7.40-7.43 (m, 1H), 7.60 (m, 1H), 8.55 (s, 2H).