(3-Methoxyphenyl)boronic acid → HCID 59753886, compound

HRID 750883Notes

Reaction equation

HRID 750883 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:29]=[CH:30][C:31]=1[F:32])[O:5][C:6]1[N:11]=[C:10]([O:12][CH3:13])[C:9](S(C(F)(F)F)(=O)=O)=[C:8]([C:21]2[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][C:22]=2[Cl:28])[N:7]=1.[CH3:33][O:34][C:35]1[CH:36]=[C:37](B(O)O)[CH:38]=[CH:39][CH:40]=1>>[F:1][C:2]1[CH:3]=[C:4]([CH:29]=[CH:30][C:31]=1[F:32])[O:5][C:6]1[N:11]=[C:10]([O:12][CH3:13])[C:9]([C:39]2[CH:38]=[CH:37][CH:36]=[C:35]([O:34][CH3:33])[CH:40]=2)=[C:8]([C:21]2[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][C:22]=2[Cl:28])[N:7]=1

Participants

3

Reactant 2

HCID 2734370(3-Methoxyphenyl)boronic acidHCID 86601403HCID 86601403, compound

Product 1

HCID 59753886HCID 59753886, compound

Procedure

This derivative was prepared by the method described in Example 132 using 2-(3,4-difluorophenoxy)-4-methoxy-5-trifluoromethansulfonyl-6-[2,4-dichlorophenyl]pyrimidine (53 mg, 0.1 mmol) as described in Reference Example 17 and 3-methoxybenzeneboronic acid (Lancaster, 16 mg, 0.1 mmol). HPLC Rt=4.63 min. 1H-NMR 500 MHz (CDCl3): 3.77 (s, 3H), 4.12 (s, 3H), 6.51 (m, 1H), 6.72 (m, 2H), 6.75 (m, 1H), 6.90 (dd, J=8 Hz, J=2 Hz, 1H), 7.07 (q, J=9 Hz, 1H), 7.25 (t, J=4 Hz, 1H), 7.43 (d, J=2 Hz, 2H), 7.49 (d, J=2 Hz, 1H).

Workup

  1. customThis derivative was prepared by the method

Sources & evidence

ORD record
ord-0aee4ec265314b81aa353a734de6e5be
Source dataset
uspto-grants-2008_07
Patent number
US07405221B2

Reaction notes

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