HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 750905Generated: October 31, 2026
Chlorotrimethylsilane → 4-(4-Trimethylsilyloxy-piperidin-1-yl)-3-fluoronitrobenzene
https://huagongshe.com/reaction/750905
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Chlorotrimethylsilane | HCID 6397 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-(2-Fluoro-4-nitrophenyl)piperidin-4-one | HCID 3763781 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-(4-Trimethylsilyloxy-piperidin-1-yl)-3-fluoronitrobenzene | HCID 69310275 | 86% |
Reaction Steps
The mixture of 4-(4-oxo-piperidin-1-yl)-3-fluoronitrobenzene (0.250 mol), triethylamine (1.250 mol), trimethylsilylchloride (0.750 mol) in dimethylformamide was heated at 70° C. for 24 h. The solvent was removed under vacuum and to the residual mass was extracted with the ethyl acetate water mixture. The combined organic layer was dried and after removal of the solvent afforded title compound as a solid in 86% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07405228B2 |
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| Source dataset | uspto-grants-2008_07 |
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| ORD ID | ord-1257c62a67044f35b69da57fd762b085 |
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| Source note | uspto-grants-2008_07 |
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