反应详情

温度

70 °C

The mixture of 4-(4-oxo-piperidin-1-yl)-3-fluoronitrobenzene (0.250 mol), triethylamine (1.250 mol), trimethylsilylchloride (0.750 mol) in dimethylformamide was heated at 70° C. for 24 h. The solvent was removed under vacuum and to the residual mass was extracted with the ethyl acetate water mixture. The combined organic layer was dried and after removal of the solvent afforded title compound as a solid in 86% yield.

1. customThe solvent was removed under vacuum and to the residual mass
2. extractionwas extracted with the ethyl acetate water mixture
3. customThe combined organic layer was dried
4. customafter removal of the solvent