Cyanoacetic acid → HCID 69312991, compound

HRID 750927Notes

Reaction equation

HRID 750927 reaction equation
[C:1]([CH:3]=[C:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:15]=[CH:14][C:13]([N:16]3[CH2:20][C@H:19]([CH2:21][NH2:22])[O:18][C:17]3=[O:23])=[CH:12][C:11]=2[F:24])[CH2:6][CH:5]1[CH3:25])#[N:2].[C:26]([CH2:28][C:29](O)=[O:30])#[N:27]>>[C:1]([CH:3]=[C:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:15]=[CH:14][C:13]([N:16]3[CH2:20][C@H:19]([CH2:21][NH:22][C:29](=[O:30])[CH2:28][C:26]#[N:27])[O:18][C:17]3=[O:23])=[CH:12][C:11]=2[F:24])[CH2:6][CH:5]1[CH3:25])#[N:2]

Participants

3

Reactant 2

HCID 9740Cyanoacetic acidHCID 69316003HCID 69316003, compound

Product 1

HCID 69312991HCID 69312991, compoundYield 81%

Procedure

The title compound was prepared as per Example-29 by using (S)-N-{3-[4-(4-cyanomethylidene-3-methylpiperidin-1-yl)-3-fluorophenyl]-2-oxo-oxazolidin-5-ylmethyl}-amine and cyanoacetic acid in 81% yield.

Sources & evidence

ORD record
ord-5d72915e5fc1451e92014b387637d21f
Source dataset
uspto-grants-2008_07
Patent number
US07405228B2

Reaction notes

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