反应详情

The mixture of (S)-N-{3-[4-(4-oxo-piperidin-1-yl)-3-fluorophenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide (2.86 mmol), cyclopropylacetonitrile (5.73 mmol), ammonium acetate (catalytic) in 100 ml of toluene was heated at reflux temperature for 5 to 6 hours. The reaction mixture was cooled to room temperature and extracted with ethyl acetate water mixture, dried and evaporated to give crude product. The crude product was recrystallized from ethyl acetate to furnish title compound in 69% yield.

1. temperaturewas heated
2. temperatureat reflux temperature for 5 to 6 hours
3. extractionextracted with ethyl acetate water mixture
4. customdried
5. customevaporated
6. customto give crude product
7. customThe crude product was recrystallized from ethyl acetate