反应详情

A mixture consisting of 30.2 g (124 mmol) 1-(4-bromo-butyl)-4-methoxy-benzene, 19.2 g (128 mmol) sodium iodide and 508 ml acetone was heated to reflux temperature for 1 h. The resulting suspension was cooled to r.t. and the precipitated sodium bromide removed by filtration. The filtrate was stripped off the solvents by vacuum distillation and the residue distributed between water and diethyl ether. After drying of the organic phase over sodium sulphate, vacuum distillation gave 34.9 g (97%) of the title compound as slightly yellow liquid.

1. temperaturewas heated
2. temperatureto reflux temperature for 1 h
3. customthe precipitated sodium bromide removed by filtration
4. distillationby vacuum distillation
5. dry with materialAfter drying of the organic phase over sodium sulphate, vacuum distillation