Hydrogen Bromide → HCID 178516003, compound

HRID 750954Notes

Reaction equation

C[O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][CH2:11][CH2:12][C:13]2[N:14]=[N:15][NH:16][CH:17]=2)=[CH:5][CH:4]=1.Br.[OH-].[Na+]>>[NH:16]1[CH:17]=[C:13]([CH2:12][CH2:11][CH2:10][CH2:9][C:6]2[CH:5]=[CH:4][C:3]([OH:2])=[CH:8][CH:7]=2)[N:14]=[N:15]1

Participants

Reactant 3

HCID 260Hydrogen Bromide

HCID 14798Sodium Hydroxide

HCID 178490075HCID 178490075, compound

Product 1

HCID 178516003HCID 178516003, compound

Conditions

Temperature: 80 °C

Procedure

A mixture of 500 mg 4-(4-(4-methoxy-phenyl)-butyl)-1H-[1,2,3]triazole and 1.5 ml 48% hydrobromic acid was stirred at 80° C. for 9 h. After adjustment to pH=6 by addition of conc. sodium hydroxide solution, the aqueous layer was discarded and the remaining sticky residue purified by HPLC-MS(RP18, methanol/water 7:3, pH=2.3). Yield 170 mg (36%).

Workup

customthe remaining sticky residue purified by HPLC-MS(RP18, methanol/water 7:3, pH=2.3)

Sources & evidence

ORD record: ord-daac76b6b3534563ad62b06edf58d554
Source dataset: uspto-grants-2008_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07405231B2

Reaction notes

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