Triethylamine → 1-Allyloxy-4-chloromethyl-benzene

HRID 750959노트

반응식

HRID 750959 반응식
CS([Cl:5])(=O)=O.[CH2:6]([O:9][C:10]1[CH:15]=[CH:14][C:13]([CH2:16]O)=[CH:12][CH:11]=1)[CH:7]=[CH2:8].C(N(CC)CC)C>ClCCl>[CH2:6]([O:9][C:10]1[CH:15]=[CH:14][C:13]([CH2:16][Cl:5])=[CH:12][CH:11]=1)[CH:7]=[CH2:8]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 11744970(4-(Prop-2-en-1-yloxy)phenyl)methanol

생성물 1

HCID 123479361-Allyloxy-4-chloromethyl-benzene

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

7.67 g (67.0 mmol) methanesulfonyl chloride were given at 0° C. to a solution of 10.0 g (60.9 mmol) (4-allyloxy-phenyl)-methanol and 9.34 ml (67.0 mmol) triethylamine in 35 ml dichloromethane and stirred at r.t. overnight. The mixture was poured in ice water, extracted with dichloromethane and the organic phase dried over Na2SO4. After removal of solvents the residue was purified by chromatography on silica gel (ethyl acetate/n-heptane 1:5) to yield 3.12 g (28%) pale yellow oil.

후처리

  1. extractionextracted with dichloromethane
  2. dry with materialthe organic phase dried over Na2SO4
  3. customAfter removal of solvents the residue
  4. customwas purified by chromatography on silica gel (ethyl acetate/n-heptane 1:5)
  5. customto yield 3.12 g (28%)

출처 및 근거

ORD 기록
ord-8f48cb6661d04d50a1cb21019ab31ecf
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07405231B2

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